Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.
نویسندگان
چکیده
منابع مشابه
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self- reactive T cells
The Nur77/Nurr1 family of DNA binding proteins has been reported to be required for the signal transduction of CD3/T cell receptor (TCR)-mediated apoptosis in T cell hybridomas. To determine the role of this family of DNA-binding proteins in thymic clonal deletion, transgenic (Tg) mice bearing a dominant negative mutation were produced. The transgene consisted of a truncated Nur77 (deltaNur77) ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1996
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.183.4.1879